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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized as focusing on practical aspects of study design that include the recruitment process and consent, adhering and the use of routinely available equipment.

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Pragmatic is a software developer that offers a broad range of casino games on online gambling platforms. Its iGaming software is used by leading operators and land based casinos. The company provides front-end design tools, analysis, marketing, promotions, payment systems, security, customer service, and bug reporting. The company also offers security, high-quality graphics, gameplay and security.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and included participants from different geographical regions. This type of heterogeneity that is crucial for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. However, too much heterogeneity, can cause problems with the trial design.

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Pragmatic Play offers not only mobile-friendly slot machines but also table games and live casino. Pragmatic Play is licensed by a variety of regulatory bodies which include Malta Gaming Authority and UK Gambling Commission. Its games are backed by high-end encryption, and the company's security team is available to assist players with any issues they might face.

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Legality

Pragmatic Play has gained a reputation for offering top-notch games and an exceptional user experience. Its software is designed to work on mobile devices and is compatible with multiple languages. It has earned itself the status of one of the most popular gaming platforms in the casino industry despite its relative infancy. Wolves is one of the latest games, a 5-reel slot machine that has a high RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to simulate real-life scenarios and to achieve maximum validity externally. They are usually requested by policy makers and practitioners to guide their decision-making. They can also be used to assess the causality of an intervention and its results. They should not, however, be used to replace explanatory studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis, and pragmatic trials, which inform the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the traits of a practical study which includes the recruitment, design, and delivery of the intervention, and follow-up.

There is a growing increase in the number pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatics. However, it is important to remember that the majority of these trials were conducted in primary care settings.